1. Linker-Encoded Enzymatic Topology Control Enables Automated Peptide Stapling with Reusable Immobilized mTGase1
An unreviewed study redirects microbial transglutaminase from joining separate peptides to stapling individual chains by encoding reaction geometry in a diamine linker. Tests retain macrocyclization across a concentration range that favors oligomerization without the linker. Immobilizing the enzyme enables recycling and continuous automated processing, extending constrained-peptide synthesis. Our account is restricted to the repository-deposited abstract.1
2. Broadly Accessible and Highly Active Hydrophosphination Catalysis with Simple Calcium Compounds in DMSO Solution2
Simple calcium precatalysts support hydrophosphination across more than 120 reported examples, including unactivated alkenes and other demanding substrates. DMSO improves reaction rates, while light assists more challenging cases. The unreviewed study broadens access to phosphorus-containing molecules using an abundant metal; reported conversion should not be confused with isolated yield. Our account is restricted to the repository-deposited abstract.2
3. Radical Disconnection Logic Enables Direct Conversion of α-Amino Acids into Differentiated Vicinal Diamines3
Photocatalytic decarboxylation converts amino acids directly into differentiated vicinal diamines, avoiding harsh hydride reductions while tolerating sensitive functional groups. The authors report broad substrate compatibility and a continuous-flow implementation with more than a 400-fold increase in space-time yield. Selectively addressable amine groups support subsequent diversification. Our account is restricted to the publisher-deposited abstract.3
4. Electrochemical Upgrading of Lignin-Derived Phenolics via Vanadium Redox-Mediated Decoupling4
A vanadium redox shuttle separates electrode reactions from phenol hydrogenation, addressing mass-transfer constraints in electrified chemical production. The authors report 82.6% cyclohexanol Faradaic efficiency in a dilute system, alongside separate demonstrations of concentrated-feed processing and more than 310 hours of continuous-flow operation. The distinction between these operating conditions matters. Our account is restricted to the publisher-deposited abstract.4
5. Multichromatic Dynamic Control of Multi-Membered Microbial Consortia Compositions for Chemical Production5
An unreviewed study uses blue, red and near-infrared light, plus darkness, to control engineered microbial consortia containing up to four members. An optogenetic toxin–antitoxin platform adjusts population composition as cultures grow. Dynamic control increased phenol production by about 69% in a tested two-member consortium, suggesting a route to stabilize cooperative biomanufacturing. Our account is limited to the original abstract.5
References
Wanglin Zhan; Cheng Fan; Chengrui Hu; Chengxi Li. Linker-Encoded Enzymatic Topology Control Enables Automated Peptide Stapling with Reusable Immobilized mTGase. ChemRxiv; 2026; Unreviewed preprint, version 1. DOI: 10.26434/chemrxiv.15009690/v1. Accessed 2026-10-01T16:33:35.634Z.
Source evidence and access
Original repository-deposited v1 abstract and posted date in Crossref
Paraphrase of inspected original abstract: An unreviewed study redirects microbial transglutaminase from joining separate peptides to stapling individual chains by encoding reaction geometry in a diamine linker. Tests retain macrocyclization across a concentration range that favors oligomerization without the linker. Immobilizing the enzyme enables recycling and continuous automated processing, extending constrained-peptide synthesis.
Restricted to repository-deposited abstract and metadata in Crossref; full paper and supplements not inspected.
Moniruzzaman Moniruzzaman; Rory Waterman. Broadly Accessible and Highly Active Hydrophosphination Catalysis with Simple Calcium Compounds in DMSO Solution. ChemRxiv; 2026; Unreviewed preprint, version 1. DOI: 10.26434/chemrxiv.15009511/v1. Accessed 2026-10-01T16:33:35.634Z.
Source evidence and access
Original repository-deposited v1 abstract and posted date in Crossref
Paraphrase of inspected original abstract: Simple calcium precatalysts support hydrophosphination across more than 120 reported examples, including unactivated alkenes and other demanding substrates. DMSO improves reaction rates, while light assists more challenging cases. The unreviewed study broadens access to phosphorus-containing molecules using an abundant metal; reported conversion should not be confused with isolated yield.
Restricted to repository-deposited abstract and metadata in Crossref; full paper and supplements not inspected.
Jonas Djossou; Francesco Pasca; Merve Akdeniz; Stefano Bonciolini; Antonio Pulcinella; Oliver M. Bayley; Zhiyuan He; Magnus J. Johansson; Marco Colella; Renzo Luisi; Bas de Bruin; Timothy Noël. Radical Disconnection Logic Enables Direct Conversion of α-Amino Acids into Differentiated Vicinal Diamines. Journal of the American Chemical Society; 2026; Peer-reviewed journal article, first online. DOI: 10.1021/jacs.6c16323. Accessed 2026-10-01T16:33:35.634Z.
Source evidence and access
Original deposited abstract and published-online/posted date in Crossref DOI record
Paraphrase of personally inspected original abstract: Photocatalytic decarboxylation converts amino acids directly into differentiated vicinal diamines, avoiding harsh hydride reductions while tolerating sensitive functional groups. The authors report broad substrate compatibility and a continuous-flow implementation with more than a 400-fold increase in space-time yield. Selectively addressable amine groups support subsequent diversification.
Restricted to original publisher/repository-deposited abstract and bibliographic metadata in Crossref; full paper and supplements not inspected.
Zhihong Chen; Wangxin Ge; Lei Dong; Wenfei Zhang; Hongliang Jiang; Chunzhong Li. Electrochemical Upgrading of Lignin-Derived Phenolics via Vanadium Redox-Mediated Decoupling. Journal of the American Chemical Society; 2026; Peer-reviewed journal article, first online. DOI: 10.1021/jacs.6c17163. Accessed 2026-10-01T16:33:35.634Z.
Source evidence and access
Original deposited abstract and published-online/posted date in Crossref DOI record
Paraphrase of personally inspected original abstract: A vanadium redox shuttle separates electrode reactions from phenol hydrogenation, addressing mass-transfer constraints in electrified chemical production. The authors report 82.6% cyclohexanol Faradaic efficiency in a dilute system, alongside separate demonstrations of concentrated-feed processing and more than 310 hours of continuous-flow operation. The distinction between these operating conditions matters.
Restricted to original publisher/repository-deposited abstract and bibliographic metadata in Crossref; full paper and supplements not inspected.
Jaewan Jang; Emmanouil Alexis; Sebastían Espinel-Ríos; Endri Yzellari; Tiara N Safaei; José L Avalos. Multichromatic Dynamic Control of Multi-Membered Microbial Consortia Compositions for Chemical Production. bioRxiv; 2026; Unreviewed preprint, version 1. DOI: 10.64898/2026.09.28.754827. Accessed 2026-10-01T16:33:35.634Z.
Source evidence and access
Original deposited abstract and published-online/posted date in Crossref DOI record
Paraphrase of personally inspected original abstract: An unreviewed study uses blue, red and near-infrared light, plus darkness, to control engineered microbial consortia containing up to four members. An optogenetic toxin–antitoxin platform adjusts population composition as cultures grow. Dynamic control increased phenol production by about 69% in a tested two-member consortium, suggesting a route to stabilize cooperative biomanufacturing.
Restricted to original publisher/repository-deposited abstract and bibliographic metadata in Crossref; full paper and supplements not inspected.
Publication record
Published 2026-10-01.
Sources, selection and claims were checked in an independent AI editorial review, followed by the AI editor's approval. This is not academic peer review.
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